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Rick Santorum took his re-energized Republican presidential campaign to Puerto Rico on Wednesday after key primary victories in the South that raised questions about conservative rival Newt Gingrich's viability as a candidate and portended a long battle with frontrunner Mitt Romney.

Actor and director George Clooney will testify before Congress Wednesday, a day after returning from a trip to a dangerous area under frequent attacks in Sudan.

William Bennett says that the evangelical patriarch's recent support of marijuana legalization couldn't be more misguided

A 6.8-magnitude earthquake shook northeastern Japan on Wednesday, according to the U.S. Geological Survey.

After a day of basketball, British Prime Minister David Cameron and President Barack Obama will get down to business on the second day of his trip to the United States.

A bus crashed into a tunnel in Switzerland, killing 28 people, including 22 children, Tuesday night, police said.

It's late in Iran on a dark night, moonless or with heavy clouds. Suddenly the silence is broken by sonic booms, followed by the sound of jets roaring overhead.

A U.S. soldier accused of killing civilians was flown out of Afghanistan. Separately, a stolen vehicle caused the U.S. defense secretary's plane to be diverted after landing.

The civilian death toll mounted in Syria Wednesday as the U.N.-Arab League envoy for the country, Kofi Annan, considered a response from Syrian authorities to proposals laid out in weekend meetings, officials said.

Former Illinois Gov. Rod Blagojevich made what's expected to be his final speech before he heads to Colorado to start a prison sentence after a corruption conviction.

Jury begins deliberations Wednesday in the trial of a former Rutgers student accused of spying on and intimidating his gay roommate, who later killed himself by jumping off New York's George Washington Bridge.

For several fear-filled minutes last Friday, three passengers on board American Airlines flight 2332 in Dallas called emergency dispatchers to report a flight attendant's apparent meltdown, asking for help and trying to make sense of her strange rant.

Twelve victims were being transported to Washington County Memorial Hospital after a school bus overturned in Missouri, a hospital spokeswoman said Tuesday.

The set construction coordinator for "Desperate Housewives" testified Tuesday he received an e-mail that suggested a "conspiracy to cover up" information regarding actress Nicollette Sheridan's lawsuit against ABC and the TV show's producers.

You might excuse Ben Silbermann, co-founder and CEO of photo-sharing site Pinterest, if he looks a little overwhelmed these days.

Doobie Brothers drummer Michael Hossack died at his home in Dubois, Wyoming, on Monday at the age of 65.

No matter what you call it, British Prime Minister David Cameron's trip to the United States is intended to demonstrate that ties between the countries remain as close as ever.

Long before the sun even hinted at lighting the sky Sunday, an American soldier left the remote combat outpost of Camp Belambay, allegedly headed for two villages in the Panjwai district of Afghanistan's Kandahar Province.

"The killing of innocent civilians is outrageous," President Obama said today. He ordered a probe of the weekend killings of 16 civilians, allegedly by a U.S. soldier.

Alabama prosecutors will seek the death penalty against a grandmother who authorities say forced her granddaughter to run as punishment for eating chocolate, an official said Tuesday.